Associate Director, Medicinal Chemistry

Associate Director, Medicinal Chemistry

Cyteir Therapeutics, a clinical stage biotechnology company engaged in the discovery and development of novel cancer medicines, is seeking an individual with strong organic / medicinal chemistry expertise to lead and manage teams of external chemists in the design and synthesis of small molecule inhibitors of proteins associated with synthetic lethality. This associate director of medicinal chemistry will report to the Senior Vice President of chemistry.


  • Lead the design and execution of medicinal chemistry programs through external resources for all phases of drug discovery, leading to the identification of development drug candidates
  • Interpret data from cell biology, biophysical methods, ADME/PK and pharmacological assays to inform and modify current designs
  • Act as chemistry expert to solve challenging synthetic chemistry problems, maximizing efficiency of the external chemistry teams
  • Communicate effectively progress against goals in a multidisciplinary environment
  • Integrate scientific advancements from the literature into Cyteir research programs
  • Document inventions to support patent filings

Qualifications and Experience

  • Ph.D. in organic/medicinal chemistry
  • >8 years of experience in a pharmaceutical/biotech environment with a track record of delivering drug candidates
  • Experience in acting as a program or chemistry team leader on discovery programs
  • Expertise in modern synthetic / medicinal chemistry principles, state-of-art knowledge of technologies, processes, and best practices to successfully deliver on drug discovery programs
  • Demonstrated ability to solve complex chemistry problems and generate novel chemical matter as evidenced by publications and patents
  • Experience in effective management of internal and / or external scientists, including Ph.D. scientists
  • Experience in computational chemistry applied to drug discovery is a plus
  • Ability to communicate clearly and concisely with all stakeholders

Other characteristics and traits

  • High degree of scientific curiosity
  • Flexibility to move between roles, as a leader, independent contributor, and team member
  • Highly collaborative, self-motivated individual
  • Continual learner
  • Mentor / role model for other scientists
  • Results driven, multitasking capabilities

Associate Director, Medicinal Chemistry

Location: Lexington, MA