Reporting to the Head of Discovery Biology, the Scientist I/II/III will carry out innovative, laboratory research related to the discovery of new therapeutic targets and the development and implementation of small molecule screens against those targets. You will work in a laboratory-based team setting, conducting molecular, biochemical, and cell biological research. This individual will have a strong background in the life sciences, experience in basic biological research, and the requisite laboratory skills to execute a rigorous scientific plan in collaboration with other team members. You will be responsible for generating rational hypotheses and designing critical tests of those hypotheses; generation of rigorous, high-quality scientific data; meticulous record keeping; independent and supervised trouble-shooting; and timely generation of research reports.
- Participate in the identification, validation, and testing of new therapeutic targets
- Carry out molecular, biochemical, and cell biological research in the laboratory
- Devise experimental approaches to test and validate proposed new targets. Technologies and approaches include molecular genetics, cell and tissue culture, microscopy, protein and nucleic acids purification and handling, cell viability assays, tests for DNA damage/repair, assays for genomic instability and apoptosis
- Understand and implement appropriate protocols, including controls.
- Rigorous experimental design ensuring reproducibility and statistical validity.
- Design and develop novel approaches to small molecule screening, with a focus on cell-based methodologies
- Work with other team members to achieve discovery biology goals.
- PhD (or equivalent), in the biological or pharmaceutical sciences with 0-4 years industry experience; or MS in the biological or pharmaceutical sciences with 3-6 years industry experience. Level and title dependent on experience.
- Background in oncology or immunology.
- Experience with basic and advanced cell culture techniques, such as lentiviral vectors and transduction, human and animal cell biology, biochemistry, assay development and/or small molecule testing/screening
- Strong track record of productivity
- Extensive laboratory skills and knowledge of research laboratory best practices
- Solid foundation of biological knowledge
- Experience running biological assays in an industry setting
- Experience working in an integrated team environment
- Strong analytical and problem solving skills
- A collaborative work ethic and a willingness to mentor junior colleagues
- Demonstrated success meeting aggressive timelines
- Excellent organizational and record keeping skills
- Solid writing, presentation and communication skills
- Comfortable in a fast-paced environment with a willingness to be flexible and change directions quickly.
- Self-motivated individual
This is a laboratory based position in Cambridge, MA. Travel less than 10%.
- Reports To: Head of Discovery Biology
- Department: Research
- Job Location: Cambridge, MA
- Base: Laboratory